CNS / CSCN Platform Presentations

1:00pm PLATFORM PRESENTATIONS

Microfluidic Co-culture Platform for Cns Axon Myelination

A microfluidic compartmentalized co-culture platform for central nervous system (CNS) axon myelination research has been developed. The platform is composed of two compartments connected via arrays of shallow microfluidic channels that function as fluidic and physical isolation barrier between the two compartments. Neurons from E 16-18 rats and oligodendrocytes (OLs) from P1-2 rats were cocultu...

Transport characteristics of a novel peptide platform for CNS therapeutics

New and effective therapeutics that cross the blood-brain barrier (BBB) are critically needed for treatment of many brain diseases. We characterize here a novel drug development platform that is broadly applicable for the development of new therapeutics with increased brain penetration. The platform is based on the Angiopep-2 peptide, a sequence derived from ligands that bind to low-density lip...

Neuron Aggregate Culture Platform for in Vitro Cns Myelination Study

A cell culture platform for neuron aggregates has been designed and fabricated as an in vitro model for studying CNS myelination. The device is composed of nine culture chambers each of which has 55 cell trapping sites for culturing neuron aggregates in a spatially controlled environments in parallel. Neuron aggregates prepared from embryonic day 16 rat fetus were cultured with oligodendrocyte ...

Oral Presentations Oral Presentations

ORAL PRESENTATIONS Discussion: Cross-resistance to different antibacterial agents including quinolones and nalidixic acid, chloramphenicol, trimethoprim and in some cases b-lactam antibiotics is a common phenomenon in Gram-negative bacteria (Gutmann et al., 1995). In this study adaptive resistance in Salmonella enterica and E. coli O157, O55 and K-12 was readily achieved by passage in sublethal...